Evidence/4

This Evidence resource describes the efficacy of placebo, from a systematic review evaluating acupuncture for the prevention of episodic migraine.

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FHIR JSON

{
  "resourceType" : "Evidence",
  "extension" : [ {
    "url" : "https://treatments.telix.health/implementationguide/extensions/study-country",
    "valueCodeableConcept" : {
      "coding" : [ {
        "system" : "https://hl7.org/fhir/ValueSet/country",
        "code" : "BR",
        "display" : "Brazil"
      }, {
        "system" : "https://hl7.org/fhir/ValueSet/country",
        "code" : "CN",
        "display" : "China"
      }, {
        "system" : "https://hl7.org/fhir/ValueSet/country",
        "code" : "DE",
        "display" : "Germany"
      }, {
        "system" : "https://hl7.org/fhir/ValueSet/country",
        "code" : "IT",
        "display" : "Italy"
      }, {
        "system" : "https://hl7.org/fhir/ValueSet/country",
        "code" : "GB",
        "display" : "United Kingdom"
      } ]
    }
  } ],
  "identifier" : [ {
    "use" : "official",
    "system" : "https://interneb.org/global-computable-evidence-identifiers",
    "value" : "migraine-acupuncture-10.1002-14651858-cd001218-pub3"
  } ],
  "title" : "This Evidence resource describes the efficacy of placebo, from a systematic review evaluating acupuncture for the prevention of episodic migraine.",
  "status" : "active",
  "date" : "2016-06",
  "publisher" : "Linca Telecomunicações Ltda",
  "author" : [ {
    "name" : "Marina Ghisi",
    "telecom" : [ {
      "system" : "email",
      "value" : "marina@linca.net.br"
    } ]
  } ],
  "useContext" : [ {
    "code" : {
      "system" : "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
      "code" : "population",
      "display" : "Population"
    },
    "valueCodeableConcept" : {
      "coding" : [ {
        "system" : "https://icd.who.int/ct/icd11_mms/en",
        "version" : "2026-01",
        "code" : "8A80",
        "display" : "Migraine"
      } ]
    }
  }, {
    "code" : {
      "system" : "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
      "code" : "comparator",
      "display" : "Comparator"
    },
    "valueCodeableConcept" : {
      "coding" : [ {
        "system" : "https://atcddd.fhi.no/atc_ddd_index/",
        "code" : "V03AX10",
        "display" : "Placebo"
      } ]
    }
  }, {
    "code" : {
      "system" : "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
      "code" : "outcome-measure",
      "display" : "Outcome Measure"
    },
    "valueCodeableConcept" : {
      "coding" : [ {
        "system" : "https://terminology.hl7.org/7.1.0/en/ValueSet-research-study-purpose-type.html",
        "code" : "efficacy",
        "display" : "Efficacy Study"
      } ]
    }
  } ],
  "relatedArtifact" : [ {
    "type" : "citation",
    "display" : "Klaus Linde et al. Cochrane Database of Systematic Reviews, 06 / 2016",
    "document" : {
      "url" : "https://doi.org/10.1002/14651858.CD001218.pub3",
      "title" : "Acupuncture for the prevention of episodic migraine"
    }
  } ],
  "variableDefinition" : [ {
    "description" : "Efficacy is calculated as the number of people who had a specific benefit from the treatment divided by the number of people who used or underwent the treatment. The specific benefits are categorized as the code system below.",
    "variableRole" : {
      "coding" : [ {
        "system" : "https://www.hl7.org/fhir/valueset-variable-role.html",
        "code" : "measuredVariable",
        "display" : "Measured Variable"
      } ]
    }
  } ],
  "studyDesign" : [ {
    "coding" : [ {
      "system" : "https://hl7.org/fhir/codesystem-study-design.html",
      "code" : "synthesis-type",
      "display" : "Systematic Review and Meta-Analysis"
    } ]
  } ],
  "statistic" : [ {
    "description" : "Efficacy calculated based on patients who achieved a positive outcome when using the placebo as a preventive measure against the disease.",
    "category" : {
      "coding" : [ {
        "system" : "https://treatments.telix.health/codesystem/categorized-efficacy-outcomes",
        "code" : "persistent reduction of symptoms",
        "display" : "Persistent reduction of symptoms"
      } ]
    },
    "numberOfEvents" : 322,
    "numberAffected" : 21,
    "sampleSize" : {
      "numberOfParticipants" : 4985
    }
  } ],
  "id" : "4"
}