Evidence/28

This Evidence resource describes an open-label clinical study evaluating olmesartan medoxomil-based treatment for hypertension.

Open raw JSON

FHIR JSON

{
  "resourceType" : "Evidence",
  "extension" : [ {
    "url" : "https://treatments.telix.health/implementationguide/extensions/study-country",
    "valueCodeableConcept" : {
      "coding" : [ {
        "system" : "urn:iso:std:iso:3166",
        "code" : "US",
        "display" : "United States"
      } ]
    }
  } ],
  "identifier" : [ {
    "use" : "official",
    "system" : "https://interneb.org/global-computable-evidence-identifiers",
    "value" : "hypertension-olmesartan-medoxomil-10-1111-j-1524-6175-2006-03304-x"
  } ],
  "title" : "This Evidence resource describes an open-label clinical study evaluating olmesartan medoxomil-based treatment for hypertension.",
  "status" : "active",
  "date" : "2004-04",
  "author" : [ {
    "name" : "diuary machado",
    "telecom" : [ {
      "system" : "email",
      "value" : "diuarymachado@gmail.com"
    } ]
  } ],
  "useContext" : [ {
    "code" : {
      "system" : "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
      "code" : "population",
      "display" : "Population"
    },
    "valueCodeableConcept" : {
      "coding" : [ {
        "system" : "https://icd.who.int/ct/icd11_mms/en",
        "code" : "BA00.Z",
        "display" : "Essential hypertension, unspecified",
        "version" : "2026-01"
      } ]
    }
  }, {
    "code" : {
      "system" : "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
      "code" : "intervention",
      "display" : "Intervention"
    },
    "valueCodeableConcept" : {
      "coding" : [ {
        "system" : "http://www.nlm.nih.gov/research/umls/rxnorm",
        "code" : "118463",
        "display" : "olmesartan medoxomil"
      } ]
    }
  }, {
    "code" : {
      "system" : "https://build.fhir.org/ig/HL7/ebm/en/ValueSet-179431.html",
      "code" : "outcome-measure",
      "display" : "Outcome Measure"
    },
    "valueCodeableConcept" : {
      "coding" : [ {
        "system" : "https://terminology.hl7.org/7.1.0/en/ValueSet-research-study-purpose-type.html",
        "code" : "efficacy",
        "display" : "Efficacy"
      } ]
    }
  } ],
  "relatedArtifact" : [ {
    "type" : "citation",
    "display" : "Joel M. Neutel et al. The Journal of Clinical Hypertension (Wiley), 04 / 2004",
    "document" : {
      "url" : "https://doi.org/10.1111/j.1524-6175.2006.03304.x",
      "title" : "Use of an Olmesartan Medoxomil‐Based Treatment Algorithm for Hypertension Control"
    }
  } ],
  "variableDefinition" : [ {
    "description" : "Efficacy is calculated as the number of people who had a specific benefit from the treatment divided by the number of people who used or underwent the treatment. The specific benefits are categorized as the code system below.",
    "variableRole" : {
      "coding" : [ {
        "system" : "https://www.hl7.org/fhir/valueset-variable-role.html",
        "code" : "measuredVariable",
        "display" : "Measured Variable"
      } ]
    }
  } ],
  "studyDesign" : [ {
    "coding" : [ {
      "system" : "https://hl7.org/fhir/codesystem-study-design.html",
      "code" : "SEVCO:1022",
      "display" : "Population Based Design"
    } ]
  } ],
  "statistic" : [ {
    "description" : "Efficacy calculated based on patients who achieved a persistent reduction in the intensity, frequency, or variety of symptoms with the use of the treatment.",
    "category" : {
      "coding" : [ {
        "system" : "https://treatments.telix.health/codesystem/categorized-efficacy-outcomes",
        "code" : "persistent-reduction",
        "display" : "Persistent reduction of symptoms/indicators"
      } ]
    },
    "numberOfEvents" : 200,
    "numberAffected" : 176,
    "sampleSize" : {
      "numberOfParticipants" : 201
    }
  } ],
  "id" : "28"
}