# title
This Evidence resource describes the placebo comparator used in a study evaluating Topamax for Migraine.

# relatedArtifact[].display
Debashish Chowdhury et al. Cephalalgia (SAGE Publications), 08 / 2022

# relatedArtifact[].document.title
Efficacy and tolerability of combination treatment of topiramate and greater occipital nerve block versus topiramate monotherapy for the preventive treatment of chronic migraine: A randomized controlled trial

# variableDefinition[].description
Efficacy is calculated as the number of people who had a specific benefit from the placebo comparator divided by the number of people who received the placebo comparator. The specific benefits are categorized as the code system below.

# statistic[].description
Efficacy calculated based on participants who achieved a persistent reduction in the intensity, frequency, or variety of symptoms in the placebo comparator group.