# title
Randomized clinical trial conducted in India with 125 participants with chronic migraine. The study evaluated whether greater occipital nerve block, combined with topiramate, helped reduce monthly headache days. The treatment groups showed significant improvement, especially in achieving at least a 50% reduction in headache days by the third month.

# relatedArtifact[].display
Debashish Chowdhury et al. Cephalalgia (SAGE Publications), 08 / 2022

# relatedArtifact[].document.title
Efficacy and tolerability of combination treatment of topiramate and greater occipital nerve block versus topiramate monotherapy for the preventive treatment of chronic migraine: A randomized controlled trial

# variableDefinition[].description
Efficacy is calculated as the number of people who had a specific benefit from the treatment divided by the number of people who used or underwent the treatment. The specific benefits are categorized as the code system below.

# statistic[].description
Efficacy calculated based on patients who achieved a persistent reduction in the intensity, frequency, or variety of symptoms with the use of the treatment.